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Soon the medication actually begins to cause the headache and it becomes very difficult to treat. The only remedy is to withdraw from all pain relief until the headache resolves itself. This can be weeks to months. I assume we all have very different underlying pathologies (right word?) that lead to the same disease. Mine seems to be an endorphin/enkephalin issue, as opioids make both my anxiety depression vanish even at the lowest of doses. For some people it serotonin or dopamine.
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